As the continuation of Mobile Suit Zeta Gundam, this series once again follows the story of the Anti Earth Union Group (AEUG) battleship Argama after Mobile Suit Zeta Gundam‍ '​s final episode. To fight off the Axis Zeon, now called the Neo Zeon, Captain Bright Noa recruits a group of teenage junk collectors led by the loudmouthed but powerful Newtype Judau Ashta to pilot the Argama‍ '​s mobile suits. Now sporting a line-up of the behemoth ZZ Gundam and the returningZeta Gundam, Gundam Mk-II and the Hyaku Shiki, the group is nicknamed the Gundam Team. As such, this became the first of a number of Gundam series where a team of Gundam mobile suits fight alongside each other regularly. The climax takes place at Side 3 in the Battle of Axis.

Out of the major Mobile Suit Zeta Gundam characters, Captain Bright Noa and Axis leader Haman Karn are featured prominently in Mobile Suit Gundam ZZ; Hayato Kobayashi,Kamille Bidan, Fa Yuiry, Wong Lee, Yazan Gable, Mineva Lao Zabi, and the children Shinta and Qum are featured in various episodes as well; Sayla Mass, who had appeared in the first series but had no speaking role in Mobile Suit Zeta Gundam, also appeared in several episodes of Mobile Suit Gundam ZZ; Char Aznable's planned appearance was canceled when Tomino was given the go-ahead to do the Mobile Suit Gundam: Char's Counterattack movie. Yoshiyuki Tomino's original plan for the show which involved Char's return was never revealed, nor does Tomino himself remember it. Also, aside from the openings and story recap/preview episode, Amuro Ray does not make an appearance in the series either.