A respected documentary maker, hears from a friend, that his long term depression has been helped after watching a video entitled, "Food matters" and following a nutritional protocol involving high doses of vitamins, as outlined by a featured speaker in Foodmatters, by the name of Andrew W Saul. Beatie visits Saul and is given an outline of Orthomolecular Medicine, the protocol envisaged by Nobel prize winners and eminent scientists.